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The 12% body weight loss during the weight loss phase led to marked decreases in plasma leptin and free leptin index levels and significant increase in soluble leptin receptor levels, confirming previous findings regarding the effect of weight loss on leptin activity

158,161,164,165 However, activating multiple receptors may lead to more complex side effects, and in some experiments, dual and triple agonists have indeed shown more severe side effects

A., McNair, P

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